DNAJC25 as a tumor suppressor candidate gene in breast cancer

DNAJC25 gene is a member of the HSP40 (DNAJ) family, and it was suggested as tumor suppressor in hepatocellular carcinoma. The aim this study to analyze expression, genetic/epigenetic alterations, prognostic value breast cancer. transcript levels are upregulated BT-20 ZR-75-1 cell lines downregulated MDA-MB-231 line compared non-tumorigenic mammary epithelial (MCF 10A) (P< 0.05). According UALCAN in-silico tool, clinical cancer samples show significantly reduced mRNA relative normal (P=1.47e-02). Kaplan–Meier plotter tool shows that high expression favorable for post-progression survival (P=0.0035). Point mutations or copy number variations uncommon samples. Combined bisulfite restriction analysis (COBRA) results showed promoter not methylated lines. Promoter hypomethylation also observed (Beta-value < 0.25). In conclusion, candidate having limited biomarker potential Functional studies essential reveal its role carcinogenesis.